Aug 2, 2022

Associations between aerobic fitness, negative symptoms, cognitive deficits and brain structure in schizophrenia-a cross-sectional study

Schizophrenia (Heidelberg, Germany)
Isabel Maurus, Lukas Röll, Daniel Keeser, Temmuz Karali, Boris Papazov, Alkomiet Hasan, Andrea Schmitt, Irina Papazova, Moritz Lembeck, Dusan Hirjak, Cristina E Thieme, Eliska Sykorova, Susanne Münz, Valentina Seitz, David Greska, Mattia Campana, Elias Wagner, Lisa Löhrs, Johannes Pömsl, Astrid Roeh, Berend Malchow, Katriona Keller-Varady, Birgit Ertl-Wagner, Sophia Stöcklein, Andreas Meyer-Lindenberg, Peter Falkai
Negative symptoms and cognitive deficits are common in individuals with schizophrenia, greatly affect their outcome, and have been associated with alterations in cerebral gray and white matter volume (GMV, WMV). In the last decade, aerobic endurance training has emerged as a promising intervention to alleviate these symptoms and improved aerobic fitness has been suggested as a key moderator variable. In the present study, we investigated, whether aerobic fitness is associated with fewer...