Feb 18, 2022

FLAIR MRI biomarkers of the normal appearing brain matter are related to cognition

NeuroImage. Clinical
M-A Bahsoun, M U Khan, S Mitha, A Ghazvanchahi, H Khosravani, P Jabehdar Maralani, J-C Tardif, A R Moody, P N Tyrrell, A Khademi
A novel biomarker panel was proposed to quantify macro and microstructural biomarkers from the normal-appearing brain matter (NABM) in multicentre fluid-attenuation inversion recovery (FLAIR) MRI. The NABM is composed of the white and gray matter regions of the brain, with the lesions and cerebrospinal fluid removed. The primary hypothesis was that NABM biomarkers from FLAIR MRI are related to cognitive outcome as determined by MoCA score. There were three groups of features designed for this...