May 25, 2021

Avoiding Unnecessary Biopsy: MRI-based Risk Models versus a PI-RADS and PSA Density Strategy for Clinically Significant Prostate Cancer

Radiology
Dominik Deniffel, Gerard M Healy, Xin Dong, Sangeet Ghai, Emmanuel Salinas-Miranda, Neil Fleshner, Robert Hamilton, Girish Kulkarni, Ants Toi, Theodorus van der Kwast, Alexandre Zlotta, Antonio Finelli, Nathan Perlis, Masoom A Haider
Background In validation studies, risk models for clinically significant prostate cancer (csPCa; Gleason score ≥3+4) combining multiparametric MRI and clinical factors have demonstrated poor calibration (over- and underprediction) and limited use in avoiding unnecessary prostate biopsies. Purpose MRI-based risk models following local recalibration were compared with a strategy that combined Prostate Imaging Data and Reporting System (PI-RADS; version 2) and prostate-specific antigen density...