Mar 26, 2022

Fronto-Parietal and White Matter Haemodynamics Predict Cognitive Outcome in Children with Moyamoya Independent of Stroke

Translational stroke research
Eun Jung Choi, Robyn Westmacott, Fenella J Kirkham, Amanda Robertson, Prakash Muthusami, Manohar Shroff, Mahendranath Moharir, Tricia Williams, Peter Dirks, Daune MacGregor, Mahmoud Slim, Elizabeth Pulcine, Ishvinder Bhathal, Matsanga Leyila Kaseka, Andrea Kassner, William Logan, Gabrielle deVeber, Nomazulu Dlamini
Moyamoya disease is a major arteriopathy characterised by progressive steno-occlusion of the arteries of the circle of Willis. Studies in adults with moyamoya suggest an association between abnormal fronto-parietal and white matter regional haemodynamics and cognitive impairments, even in the absence of focal infarction. However, these associations have not been investigated in children with moyamoya. We examined the relationship between regional haemodynamics and ratings of intellectual ability...