May 28, 2022

Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI

Brain sciences
Marc A Khoury, Mohamad-Ali Bahsoun, Ayad Fadhel, Shukrullah Shunbuli, Saanika Venkatesh, Abdollah Ghazvanchahi, Samir Mitha, Karissa Chan, Luis R Fornazzari, Nathan W Churchill, Zahinoor Ismail, David G Munoz, Tom A Schweizer, Alan R Moody, Corinne E Fischer, April Khademi
CONCLUSION: Cognitively impaired older adults with more severe delusions have greater global brain disease burden in the WM and GM combined (NABM) as measured using FLAIR MRI. Relative to patients with mild delusions, tissue degeneration in the NABM was more pronounced in subjects with higher delusional symptoms, with a significant association with CSF tau. Future studies are required to establish potential tau-associated mechanisms of increased delusional severity.