Mar 1, 2022

Spontaneous intracranial hypotension: searching for the CSF leak

The Lancet. Neurology
Tomas Dobrocky, Patrick Nicholson, Levin Häni, Pasquale Mordasini, Timo Krings, Waleed Brinjikji, Jeremy K Cutsforth-Gregory, Ralph Schär, Christoph Schankin, Jan Gralla, Vitor M Pereira, Andreas Raabe, Richard Farb, Jürgen Beck, Eike I Piechowiak
Spontaneous intracranial hypotension is caused by loss of CSF at the level of the spine. The most frequent symptom of this disorder is orthostatic headache, with the headache worsening in the upright position and subsiding after lying down. Neuroimaging has a crucial role in diagnosing and monitoring spontaneous intracranial hypotension, because it provides objective (albeit often subtle) data despite the variable clinical syndromes and often normal lumbar puncture opening pressure associated...