Apr 19, 2022

MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study

Radiology
Michael Zhang, Samuel W Wong, Jason N Wright, Matthias W Wagner, Sebastian Toescu, Michelle Han, Lydia T Tam, Quan Zhou, Saman S Ahmadian, Katie Shpanskaya, Seth Lummus, Hollie Lai, Azam Eghbal, Alireza Radmanesh, Jordan Nemelka, Stephen Harward, Michael Malinzak, Suzanne Laughlin, Sébastien Perreault, Kristina R M Braun, Robert M Lober, Yoon Jae Cho, Birgit Ertl-Wagner, Chang Y Ho, Kshitij Mankad, Hannes Vogel, Samuel H Cheshier, Thomas S Jacques, Kristian Aquilina, Paul G Fisher, Michael Taylor, Tina Poussaint, Nicholas A Vitanza, Gerald A Grant, Stefan Pfister, Eric Thompson, Alok Jaju, Vijay Ramaswamy, Kristen W Yeom
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection of patient groups suitable for targeted genetic analysis. Purpose To develop machine learning strategies that identify the four clinically significant MB molecular subgroups. Materials and Methods In this retrospective study, consecutive pediatric patients with newly diagnosed MB at MRI at 12 international...