Jul 1, 2021

Normal BOLD Response to a Step CO2 Stimulus After Correction for Partial Volume Averaging

Frontiers in physiology
Julien Poublanc, Reema Shafi, Olivia Sobczyk, Kevin Sam, Daniel M Mandell, Lakshmikumar Venkatraghavan, James Duffin, Joseph A Fisher, David J Mikulis
Cerebrovascular reactivity (CVR) is defined as the change in cerebral blood flow induced by a change in a vasoactive stimulus. CVR using BOLD MRI in combination with changes in end-tidal CO(2) is a very useful method for assessing vascular performance. In recent years, this technique has benefited from an advanced gas delivery method where end-tidal CO(2) can be targeted, measured very precisely, and validated against arterial blood gas sampling (Ito et al., 2008). This has enabled more precise...